81 APOE MODENA: A NOVEL APOE MUTANT CAUSING LIPOPROTEIN GLOMERULOPATHY
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چکیده
منابع مشابه
A Case of Lipoprotein Glomerulopathy with apoE Chicago and apoE (Glu3Lys) Treated with Fenofibrate
Lipoprotein glomerulopathy (LPG) is characterized by the accumulation of lipoprotein thrombi within glomerular capillaries. This rare disorder is associated with various types of mutations in the apolipoprotein E gene (apoE). Herein, we present a case of LPG with a combination of apoE Chicago (Arg147Pro) and apoE (Glu3Lys) mutations. A 51-year-old Japanese woman presented with severe (3+) prote...
متن کاملA novel apolipoprotein E mutation, ApoE Tsukuba (Arg 114 Cys), in lipoprotein glomerulopathy.
Lipoprotein glomerulopathy (LPG) is considered a type of renal lipidosis, characterized by the presence of lipoprotein thrombi in markedly dilated capillary lumina of the affected glomeruli [1]. LPG is a rare disease; approximately 65 cases have been reported to date [2]. Patients with LPG exhibit proteinuria and progressive renal dysfunction. In most of the LPG patients, levels of intermediate...
متن کاملA new apolipoprotein E mutation, apoE Las Vegas, in a European-American with lipoprotein glomerulopathy.
Lipoprotein glomerulopathy is a rare disease diagnosed by unique histopathologic findings of glomerular capillary dilatation by lipoprotein thrombi. The disease is caused by mutations in apoE, the gene that encodes apolipoprotein E. To date, <80 cases have been reported in the medical literature, nearly all of which are from Japan or China. Only five cases from the United States have previously...
متن کاملAtherosclerosis, inflammation and lipoprotein glomerulopathy in kidneys of apoE-/-/LDL-/- double knockout mice
BACKGROUND The apoE-/-/LDL-/- double knockout mice are bearing considerable structural homology to human atherosclerosis. We hypothesized, that advanced lesion formation in the renal artery is associated with kidney alterations in these mice. METHODS Kidneys from apoE-/-/LDL-/- double knockout mice at the age of 80 weeks (n = 6) and C57/BL control mice (n = 5) were infused with Microfil, harv...
متن کاملAuthor's response to reviews Title: Atherosclerosis, inflammation and lipoprotein glomerulopathy in kidneys of apoE-/-/LDL-/- double knockout mice Authors:
Alexander C Langheinrich ([email protected]) Marian Kampschulte ([email protected]) Franziska Scheiter ([email protected]) Christian Dierkes ([email protected]) Philip Stieger ([email protected]) Rainer M Bohle ([email protected]) Wolfgang Weidner ([email protected]...
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ژورنال
عنوان ژورنال: Nutrition, Metabolism and Cardiovascular Diseases
سال: 2008
ISSN: 0939-4753
DOI: 10.1016/s0939-4753(08)70082-6